Amy Schumer on ‘Botched’ Colonoscopy: ‘Not Feeling Very Sexual’

Amy Schumer is nothing if not honest — and at a recent podcast event, she delivered one of her most unexpected health updates yet. The comedian told the crowd at a May 17 Dear Media event for the Not Skinny But Not Fat podcast that a medical procedure gone wrong has put a damper on her love life.

“I feel happier than I’ve ever been before,” Schumer said, before host Amanda Hirsch brought up her noticeable weight loss and asked whether feeling “really hot” had anything to do with it. Schumer appreciated the compliment but quickly redirected. “I actually had kind of a botched colonoscopy, so I’m not feeling very sexual,” she told the audience.

She didn’t get into the specifics of what went wrong during the procedure — a routine outpatient screening in which a doctor examines the large intestine for signs of colorectal cancer — but she did offer the crowd a little perspective. “See, that’s another thing you’re not going to have to worry about for 15 years,” she quipped.

A Year of Major Health Changes

The 44-year-old has been unusually candid about her body and health over the past couple of years, and for good reason. In 2024, Schumer was diagnosed with exogenous Cushing syndrome after a flood of online comments about her noticeably puffy face prompted her to look into what was happening.

“I was getting these steroid injections, and so it gave me this thing called Cushing syndrome — which I wouldn’t have known if the internet hadn’t come for me so hard,” she said on the Call Her Daddy podcast in 2025. “I learned that I had something called ‘moon face,’ and I’m starring in a movie and there’s a camera in my face, and I’m like, ‘Oh my God.”

Cushing syndrome — caused by an excess of cortisol in the body — is characterized by a round, full face, thin skin, and weight gain. Schumer wrote in a 2024 issue of the News Not Noise newsletter that learning her diagnosis felt like a turning point. “I feel reborn,” she said at the time, noting that some forms of Cushing can be fatal or require brain surgery.

As the swelling from the syndrome began to dissolve on its own, Schumer also started a weight loss journey with the help of GLP-1 medications. She’s been transparent about that process too — including the rocky start. “Three years ago, I tried Wegovy. I was puking, I couldn’t handle it. I don’t know if they’ve changed the formula, whatever,” she said in a March 2025 Instagram video. She eventually found a better fit with Mounjaro, and in December 2025 told her followers she had lost 50 pounds.

She’s also been on hormone therapy after discovering she was in perimenopause. “They put me on estrogen and progesterone because I realized I was in perimenopause and my symptoms have disappeared,” she explained in the same March video. “My hair is fuller, my skin is better, I have more energy, I want to get down more, if you know what I mean. I’m talking about sex. So that’s been great.”

Which makes the colonoscopy timing… unfortunate.

Life After the Split

Schumer’s health journey has run parallel to a major shift in her personal life. In December 2025, she announced on Instagram that she and husband Chris Fischer were ending their marriage after nearly eight years together.

“Blah blah blah Chris and I have made the difficult decision to end our marriage after 7 years. We love each other very much and will continue to focus on raising our son,” she wrote — and in true Schumer fashion, she pre-empted the tabloid speculation: “not becisse [sic] I dropped some lbs and thought I could bag a basket and not because he’s a hot James Beard award-winning chef who can still pull some hot tail. Amicable and all love and respect! Family forever.”

She filed for divorce from Fischer, 45, in January 2026. But according to a source close to the situation, the two have remained closely intertwined for the sake of their son Gene, now 7. “She expects that they’ll co-parent full-time together and that he’ll see Gene almost as much as he does now — if not more,” the insider said. “They are still largely under the same roof, for the kid’s sake.”

Through the health scares, the weight loss, the divorce, and now a colonoscopy she’d probably like a do-over on, Schumer keeps showing up and telling it straight. “I feel happier than I’ve ever been before” — botched procedure and all.