John Cena and Eric André Are Brothers in Netflix’s Little Brother Trailer

John Cena and Eric André are about to become family — whether they like it or not. Netflix has released the first trailer for Little Brother, the upcoming comedy that pairs the two in one of the more inspired odd-couple matchups in recent memory, and it’s exactly as chaotic as you’d hope.

In the film, Cena plays Rudd, a successful and meticulously put-together real estate agent whose carefully ordered life gets blown apart when Marcus — his “little brother” from a childhood charity program, played by André — resurfaces after a car accident and lands squarely in Rudd’s home. “He’s not my actual brother,” Cena’s character laments in the trailer. “The timing on this couldn’t be worse.”

And then André’s Marcus, in classic Eric André fashion, turns to Michelle Monaghan’s character and offers some unsolicited marital advice: “Our man is hurting right now. You might want to think about eating that ass.”

Yeah. It’s that kind of movie.

What to Expect From the Comedy

The film is directed by Matt Spicer, whose 2017 debut Ingrid Goes West — the darkly funny parasocial thriller with Aubrey Plaza and Elizabeth Olsen — earned him serious indie credibility. Little Brother marks his return to feature directing after nearly a decade of TV work, including episodes of On Becoming a God in Central Florida and American Horror Stories. The script comes from Jarrad Paul and Andrew Mogel, the writers behind The D-Train, and producers include Ruben Fleischer (the Zombieland films) and David Bernad for Middle Child Pictures.

Beyond Cena and André, the cast is stacked: Michelle Monaghan, Chris Meloni, Ego Nwodim, Sherry Cola, Caleb Hearon, Ben Ahlers, Bryce Gheisar, and Pilot Bunch all round out the ensemble.

Cena, for his part, sounds like he had the time of his life on set. Asked during a recent interview with Extra how he managed to keep a straight face opposite André, he didn’t even try to pretend he had it under control. “They’re only going to show the seconds that I wasn’t laughing,” he said. “I honestly think we play off each other very well. He has an incredible sense of humor, and I’m a decent sounding board for that.”

On X, Cena shared the trailer with a message that felt genuinely warm: “Families come in all shapes, sizes, and even varying levels of ‘relation.’ I couldn’t be prouder to be part of this cast and crew family. They’ll make you laugh and cry, and @EricAndre will make you often do both. So excited for everyone to see #LittleBrother on @netflix June 26.”

A Big Moment in Cena’s Hollywood Transition

Little Brother lands at an interesting moment for Cena, who retired from in-ring competition at WWE’s Saturday Night’s Main Event in December 2025 and has been leaning fully into his acting career ever since. He recently reprised his role as Christopher Smith in Peacemaker Season 2, and he’s also set to appear in the long-awaited Coyote vs. Acme — where he plays the villainous boss of a law firm squaring off against Will Forte’s hapless attorney and his client, Wile E. Coyote himself.

André, meanwhile, is having his own moment. Fresh off a supporting role in Marvel’s Ironheart, he’s gearing up to play Don Sauvage in the live-action Street Fighter movie, due in October. Safe to say both stars are very much in demand right now.

Little Brother starts streaming on Netflix June 26, 2026.